Article
The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster.
Human genetics - 1 Jun 2004
Fullerton Stephanie M, Buchanan Anne V, Sonpar Vibhor A, Taylor Scott L, Smith Joshua D, Carlson Christopher S, Salomaa Veikko, Stengård Jari H, Boerwinkle Eric, Clark Andrew G, Nickerson Deborah A, Weiss Kenneth M
Abstract excerpt
While there is considerable appeal to the idea of selecting a few SNPs to represent all, or much, of the DNA sequence variability in a local chromosomal region, it is also important to quantify what detail is lost in adopting such an approach. To address this issue, we compared high- and low-resolution depictions of sequence diversity for the same genomic region, the APOA1/C3/A4/A5 gene cluster on chromosome 11....
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