Article
Large-scale SNP analysis reveals clustered and continuous patterns of human genetic variation.
Human genomics - 1 Jun 2005
Shriver Mark D, Mei Rui, Parra Esteban J, Sonpar Vibhor, Halder Indrani, Tishkoff Sarah A, Schurr Theodore G, Zhadanov Sergev I, Osipova Ludmila P, Brutsaert Tom D, Friedlaender Jonathan, Jorde Lynn B, Watkins W Scott, Bamshad Michael J, Gutierrez Gerardo, Loi Halina, Matsuzaki Hajime, Kittles Rick A, Argyropoulos George, Fernandez Jose R, Akey Joshua M, Jones Keith W
Abstract excerpt
Understanding the distribution of human genetic variation is an important foundation for research into the genetics of common diseases. Some of the alleles that modify common disease risk are themselves likely to be common and, thus, amenable to identification using gene-association methods. A problem with this approach is that the large sample sizes required for sufficient statistical power to detect alleles...
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