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Article

In vivo validation of the mutant selection window hypothesis with moxifloxacin in a murine model of tuberculosis.

Antimicrobial agents and chemotherapy - 1 Dec 2007

Almeida Deepak, Nuermberger Eric, Tyagi Sandeep, Bishai William R, Grosset Jacques

Abstract excerpt

Combination therapy is the most effective strategy to prevent emergence of resistance during tuberculosis (TB) treatment. Another strategy, albeit theoretical, is to limit the time that drug concentrations fall in the "mutant selection window" (MSW) between the MIC and the mutant prevention concentration (MPC). Drug concentrations above the MPC prevent selective amplification of resistant mutants in vitro even...

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Identifiers

PMID: 17938193
DOI: 10.1128/AAC.01123-07
PMCID: PMC2168018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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