Article
After chitin docking, toxicity of Kluyveromyces lactis zymocin requires Saccharomyces cerevisiae plasma membrane H+-ATPase.
Cellular microbiology - 1 Jun 2004
Mehlgarten Constance, Schaffrath Raffael
Abstract excerpt
Zymocin, a three-subunit (alpha beta gamma) toxin complex from Kluyveromyces lactis, imposes a cell cycle block on Saccharomyces cerevisiae. Phenotypic analysis of the resistant kti10 mutant implies a membrane defect, suggesting that KTI10 represents a gene involved early in the zymocin response. Consistently, KTI10 is shown here to be allelic to PMA1 encoding H(+)-ATPase, a plasma membrane H(+) pump vital for...
Topics
- Alleles
- Antifungal Agents
- Chitin
- DNA, Fungal
- Drug Resistance, Fungal
- Ethanol
- Genetic Complementation Test
- Hydrogen-Ion Concentration
- Hygromycin B
- Killer Factors, Yeast
- Kluyveromyces
- Membrane Proteins
- Mutation
- Mycotoxins
- Proton-Translocating ATPases
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins