Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant casein kinase I (Hrr25p/Kti14p) abrogates the G1 cell cycle arrest induced by Kluyveromyces lactiszymocin in budding yeast.

Molecular genetics and genomics : MGG - 1 May 2003

Mehlgarten C, Schaffrath R

Abstract excerpt

Zymocin, a toxic protein complex produced by Kluyveromyces lactis, inhibits cell cycle progression in Saccharomyces cerevisiae. In studying its action, a resistant mutant ( kti14-1) was found to express the tot-phenotype typical of totDelta cells, toxin target (TOT) mutants that are impaired in RNA polymerase II Elongator function. Phenotypic analysis of a kti14-1 tot3Delta double mutant revealed a functional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Casein Kinase I
Share to Casein Kinases
Share to G1 Phase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kluyveromyces

Share to Methyl Methanesulfonate

Share to Open Reading Frames

Share to Protein Kinases

Share to Saccharomycetales

Source

Identifiers

PMID: 12756531
DOI: 10.1007/s00438-003-0807-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant casein kinase I (Hrr25p/Kti14p) abrogates the G1 cell cycle arrest induced by Kluyveromyces lactiszymocin in budding yeast.PMID 12756531Read ↗

KTI11 and KTI13, Saccharomyces cerevisiae genes controlling sensitivity to G1 arrest induced by Kluyveromyces lactis zymocin.Semantic proximity Read ↗

Defects in yeast RNA polymerase II transcription elicit hypersensitivity to G1 arrest induced by Kluyveromyces lactis zymocin.Semantic proximity Read ↗

Saccharomyces cerevisiae Elongator mutations confer resistance to the Kluyveromyces lactis zymocin.Semantic proximity Read ↗

Yeast alpha-tubulin suppressor Ats1/Kti13 relates to the Elongator complex and interacts with Elongator partner protein Kti11.Semantic proximity Read ↗

Kluyveromyces lactis zymocin mode of action is linked to RNA polymerase II function via Elongator.Semantic proximity Read ↗

Elongator function depends on antagonistic regulation by casein kinase Hrr25 and protein phosphatase Sit4.Semantic proximity Read ↗

A tti1 mutation in the Tel2-Tti1-Tti2 complex specifically eliminates the cellular function of Rad3ATR, but not that of other PIKKs in fission yeast.Semantic proximity Read ↗

Mannosyl-diinositolphospho-ceramide, the major yeast plasma membrane sphingolipid, governs toxicity of Kluyveromyces lactis zymocin.Semantic proximity Read ↗

A versatile partner of eukaryotic protein complexes that is involved in multiple biological processes: Kti11/Dph3.Semantic proximity Read ↗

Mating-type locus control of killer toxins from Kluyveromyces lactis and Pichia acaciae.Semantic proximity Read ↗

Protein interactions within Saccharomyces cerevisiae Elongator, a complex essential for Kluyveromyces lactis zymocicity.Semantic proximity Read ↗

Saccharomyces cerevisiae RNA polymerase II is affected by Kluyveromyces lactis zymocin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.