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Article

Saccharomyces cerevisiae Elongator mutations confer resistance to the Kluyveromyces lactis zymocin.

The EMBO journal - 17 Apr 2001

Frohloff F, Fichtner L, Jablonowski D, Breunig K D, Schaffrath R

Abstract excerpt

Kluyveromyces lactis killer strains secrete a zymocin complex that inhibits proliferation of sensitive yeast genera including Saccharomyces cerevisiae. In search of the putative toxin target (TOT), we used mTn3:: tagging to isolate zymocin-resistant tot mutants from budding yeast. Of these we identified the TOT1, TOT2 and TOT3 genes (isoallelic with ELP1, ELP2 and ELP3, respectively) coding for the histone...

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Share to Acetyltransferases
Share to Histone Acetyltransferases
Share to Killer Factors, Yeast

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Kluyveromyces

Share to Microtubule-Associated Proteins

Share to Mutagenesis, Insertional

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Share to RNA Polymerase II

Source

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Identifiers

PMID: 11296232
DOI: 10.1093/emboj/20.8.1993
PMCID: PMC125238

Genes

ELP1
ELP2
ELP3
KTI12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Saccharomyces cerevisiae Elongator mutations confer resistance to the Kluyveromyces lactis zymocin.PMID 11296232Read ↗

KTI11 and KTI13, Saccharomyces cerevisiae genes controlling sensitivity to G1 arrest induced by Kluyveromyces lactis zymocin.Semantic proximity Read ↗

Kluyveromyces lactis zymocin mode of action is linked to RNA polymerase II function via Elongator.Semantic proximity Read ↗

Protein interactions within Saccharomyces cerevisiae Elongator, a complex essential for Kluyveromyces lactis zymocicity.Semantic proximity Read ↗

Defects in yeast RNA polymerase II transcription elicit hypersensitivity to G1 arrest induced by Kluyveromyces lactis zymocin.Semantic proximity Read ↗

Mutant casein kinase I (Hrr25p/Kti14p) abrogates the G1 cell cycle arrest induced by Kluyveromyces lactiszymocin in budding yeast.Semantic proximity Read ↗

Yeast alpha-tubulin suppressor Ats1/Kti13 relates to the Elongator complex and interacts with Elongator partner protein Kti11.Semantic proximity Read ↗

A versatile partner of eukaryotic protein complexes that is involved in multiple biological processes: Kti11/Dph3.Semantic proximity Read ↗

Mating-type locus control of killer toxins from Kluyveromyces lactis and Pichia acaciae.Semantic proximity Read ↗

Saccharomyces cerevisiae RNA polymerase II is affected by Kluyveromyces lactis zymocin.Semantic proximity Read ↗

Mannosyl-diinositolphospho-ceramide, the major yeast plasma membrane sphingolipid, governs toxicity of Kluyveromyces lactis zymocin.Semantic proximity Read ↗

After chitin docking, toxicity of Kluyveromyces lactis zymocin requires Saccharomyces cerevisiae plasma membrane H+-ATPase.Semantic proximity Read ↗

Physical and functional interaction between Elongator and the chromatin-associated Kti12 protein.Semantic proximity Read ↗

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