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Article

Mannosyl-diinositolphospho-ceramide, the major yeast plasma membrane sphingolipid, governs toxicity of Kluyveromyces lactis zymocin.

Eukaryotic cell - 1 May 2005

Zink Sabrina, Mehlgarten Constance, Kitamoto Hiroko K, Nagase Junko, Jablonowski Daniel, Dickson Robert C, Stark Michael J R, Schaffrath Raffael

Abstract excerpt

Kluyveromyces lactis zymocin, a trimeric (alphabetagamma) protein toxin complex, inhibits proliferation of Saccharomyces cerevisiae cells. Here we present an analysis of kti6 mutants, which resist exogenous zymocin but are sensitive to intracellular expression of its inhibitory gamma-toxin subunit, suggesting that KTI6 encodes a factor needed for toxin entry into the cell. Consistent with altered cell surface...

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Identifiers

PMID: 15879522
DOI: 10.1128/EC.4.5.879-889.2005
PMCID: PMC1140091

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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