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Article

Biotransformation of methyl parathion by glutathione S-transferases.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Jun 2004

Abel Erika L, Bammler Theo K, Eaton David L

Abstract excerpt

The organo(thio)phosphate esters are one of the most widely used classes of insecticides. Worldwide, organophosphate insecticides (OPs) result in numerous poisonings each year. In insects, glutathione S-transferases (GSTs) play an important role in OP resistance; limited data suggest that GST-mediated O-dealkylation occurs in humans as well. To characterize the capacity of mammalian GSTs to detoxify OPs, we...

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Source

Identifiers

PMID: 15103050
DOI: 10.1093/toxsci/kfh118

Genes

GSTA3
GSTA5
GSTP1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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