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Computational journey to unveil organophosphorothioate pesticides' metabolism: A focus on chlorpyrifos and CYP2C19 mutational landscape.

Ecotoxicology and environmental safety - 1 Dec 2024

Pedroni Lorenzo, Perugino Florinda, Dall'Asta Chiara, Galaverna Gianni, Buratti Franca Maria, Testai Emanuela, Dellafiora Luca

Abstract excerpt

Organophosphorothioates (OPT) are pesticides impacting human, animal and environmental health. They enter the environment worldwide, primarily due to their application as insecticides. OPTs are mainly neurotoxic upon bioactivation and inhibition of brain and serum acetylcholinesterase (AChE). Although OPTs are meant to target insects, they are potentially toxic to many other species (including humans), posing...

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PMID: 39571261
DOI: 10.1016/j.ecoenv.2024.117354

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