Article
The Alternative Sigma Factors SigE and SigB Are Involved in Tolerance and Persistence to Antitubercular Drugs.
Antimicrobial agents and chemotherapy - 1 Dec 2017
Pisu Davide, Provvedi Roberta, Espinosa Dulce Mata, Payan Jorge Barrios, Boldrin Francesca, Palù Giorgio, Hernandez-Pando Rogelio, Manganelli Riccardo
Abstract excerpt
The emergence and spread of drug-resistant Mycobacterium tuberculosis strains possibly threaten our ability to treat this disease in the future. Even though two new antitubercular drugs have recently been introduced, there is still the need to design new molecules whose mechanisms of action could reduce the length of treatment. We show that two alternative sigma factors of M. tuberculosis (SigE and SigB) have a...
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