A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program.

doi:10.1093/hmg/ddh133

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Article

A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program.

Human molecular genetics - 1 Jun 2004

Inoue Maki, Sakuraba Yoshiyuki, Motegi Hiromi, Kubota Naoto, Toki Hideaki, Matsui Junko, Toyoda Yukiyasu, Miwa Ichitomo, Terauchi Yasuo, Kadowaki Takashi, Shigeyama Yutaka, Kasuga Masato, Adachi Takashi, Fujimoto Naomi, Matsumoto Rie, Tsuchihashi Keiko, Kagami Tomoko, Inoue Ayako, Kaneda Hideki, Ishijima Junko, Masuya Hiroshi, Suzuki Tomohiro, Wakana Shigeharu, Gondo Yoichi, Minowa Osamu, Shiroishi Toshihiko, Noda Tetsuo

Abstract excerpt

Mutant mouse models are indispensable tools for clarifying the functions of genes and for elucidating the underlying pathogenic mechanisms of human diseases. Currently, several large-scale mutagenesis projects that employ the chemical mutagen N-ethyl-N-nitrosourea (ENU) are underway worldwide. One specific aim of our ENU mutagenesis project is to generate diabetic mouse models. We screened 9375 animals for...

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PMID: 15102714
DOI: 10.1093/hmg/ddh133

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