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Article

Structural and mutational characterization of L-carnitine binding to human carnitine acetyltransferase.

Journal of structural biology - 1 Jun 2004

Govindasamy Lakshmanan, Kukar Thomas, Lian Wei, Pedersen Brenda, Gu Yunrong, Agbandje-McKenna Mavis, Jin Shouguang, McKenna Robert, Wu Donghai

Abstract excerpt

We report the crystal structure of a binary complex of human peroxisomal carnitine acetyltransferase and the substrate l-carnitine, refined to a resolution of 1.8 Angstrom with an R(factor) value of 18.9% (R(free)=22.3%). L-carnitine binds to a preformed pocket in the active site tunnel of carnit...

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Identifiers

PMID: 15099582
DOI: 10.1016/j.jsb.2004.01.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15099582-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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