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Article

The crystal structure of carnitine palmitoyltransferase 2 and implications for diabetes treatment.

Structure (London, England : 1993) - 1 Apr 2006

Rufer Arne C, Thoma Ralf, Benz Jörg, Stihle Martine, Gsell Bernard, De Roo Elodie, Banner David W, Mueller Francis, Chomienne Odile, Hennig Michael

Abstract excerpt

Carnitine palmitoyltransferases 1 and 2 (CPTs) facilitate the import of long-chain fatty acids into mitochondria. Modulation of the catalytic activity of the CPT system is currently under investigation for the development of novel drugs against diabetes mellitus. We report here the 1.6 A resolution structure of the full-length mitochondrial membrane protein CPT-2. The structure of CPT-2 in complex with the...

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Identifiers

PMID: 16615913
DOI: 10.1016/j.str.2006.01.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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