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Article

Definition by functional and structural analysis of two malonyl-CoA sites in carnitine palmitoyltransferase 1A.

The Journal of biological chemistry - 22 Jun 2007

López-Viñas Eduardo, Bentebibel Assia, Gurunathan Chandrashekaran, Morillas Montserrat, de Arriaga Dolores, Serra Dolors, Asins Guillermina, Hegardt Fausto G, Gómez-Puertas Paulino

Abstract excerpt

Carnitine palmitoyltransferase 1 (CPT1) catalyzes the conversion of palmitoyl-CoA to palmitoylcarnitine in the presence of l-carnitine, thus facilitating the entry of fatty acids to mitochondria, in a process that is physiologically inhibited by malonyl-CoA. To examine the mechanism of CPT1 liver isoform (CPT1A) inhibition by malonyl-CoA, we constructed an in silico model of both its NH2- and COOH-terminal...

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PMID: 17452323
DOI: 10.1074/jbc.M700885200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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