Article
Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition.
The Journal of biological chemistry - 14 Mar 2003
Morillas Montserrat, Gómez-Puertas Paulino, Bentebibel Assia, Sellés Eva, Casals Nuria, Valencia Alfonso, Hegardt Fausto G, Asins Guillermina, Serra Dolors
Abstract excerpt
Carnitine palmitoyltransferase (CPT) I, which catalyzes the conversion of palmitoyl-CoA to palmitoylcarnitine facilitating its transport through the mitochondrial membranes, is inhibited by malonyl-CoA. By using the SequenceSpace algorithm program to identify amino acids that participate in malon...
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