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Article

Choline acetyltransferase structure reveals distribution of mutations that cause motor disorders.

The EMBO journal - 19 May 2004

Cai Yiying, Cronin Ciarán N, Engel Andrew G, Ohno Kinji, Hersh Louis B, Rodgers David W

Abstract excerpt

Choline acetyltransferase (ChAT) synthesizes acetylcholine in neurons and other cell types. Decreases in ChAT activity are associated with a number of disease states, and mutations in ChAT cause congenital neuromuscular disorders. The crystal structure of ChAT reported here shows the enzyme divided into two domains with the active site in a solvent accessible tunnel at the domain interface. A low-resolution view...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15131697
DOI: 10.1038/sj.emboj.7600221
PMCID: PMC424412

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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