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Article

Early changes in hepatitis C viral quasispecies during interferon therapy predict the therapeutic outcome

5 Mar 2002

Abstract excerpt

Despite recent treatment advances, the majority of patients with chronic hepatitis C fail to respond to antiviral therapy. Although the genetic basis for this resistance is unknown, accumulated evidence suggests that changes in the heterogeneous viral population (quasispecies) may be an important determinant of viral persistence and response to therapy. Sequences within hepatitis C virus (HCV) envelope 1 and...

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PMID: 11880647
DOI: 10.1073/pnas.052712599

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