Article
Hepatitis C virus (HCV) quasispecies complexity and selection in HCV/HIV-coinfected subjects treated with interferon-based regimens.
The Journal of infectious diseases - 1 Mar 2010
Sherman Kenneth E, Rouster Susan D, Stanford Sandra, Blackard Jason T, Shire Norah, Koziel Margaret, Peters Marion, Chung Raymond T
Abstract excerpt
BACKGROUND: Coinfection with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) has emerged as a major cause of morbidity and mortality due to liver disease. Interferon-based therapy response rates have been disappointingly low. Baseline HCV complexity and the relationship between complexity and viral kinetic parameters has not been well described in HCV/HIV-coinfected subjects. METHODS: A subset of...
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