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Article

Hepatitis C virus diversity and evolution in the full open-reading frame during antiviral therapy.

PloS one - 7 May 2008

Cannon Nathan A, Donlin Maureen J, Fan Xiaofeng, Aurora Rajeev, Tavis John E

Abstract excerpt

BACKGROUND: Pegylated interferon plus ribavirin therapy for hepatitis C virus (HCV) fails in approximately half of genotype 1 patients. Treatment failure occurs either by nonresponse (minimal declines in viral titer) or relapse (robust initial responses followed by rebounds of viral titers during or after therapy). HCV is highly variable genetically. To determine if viral genetic differences contribute to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18463735
DOI: 10.1371/journal.pone.0002123
PMCID: PMC2373758

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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