Determination of the effect of calcineurin inhibitors on the rat's immune system after KLH immunisation.

doi:10.1016/j.toxlet.2003.12.027

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Article

Determination of the effect of calcineurin inhibitors on the rat's immune system after KLH immunisation.

Toxicology letters - 1 Apr 2004

Roman D, Ulrich P, Paul G, Court M, Vit P, Kehren J, Mahl A

Abstract excerpt

The calcineurin inhibitors cyclosporin A (CsA), tacrolimus (FK506) and pimecrolimus (ASM981) are on the market for the oral treatment of psoriasis and atopic dermatitis and topical treatment of atopic dermatitis, respectively. The effect of these treatments on the immune response was investigated in this study after immunisation of rats with keyhole limpet hemocyanin (KLH). Male rats (10 per group) were orally...

Topics

Adjuvants, Immunologic
Animals
Antigen-Presenting Cells
Antigens, Surface
B-Lymphocytes
Calcineurin Inhibitors
Cyclosporine
Hemocyanins
Immune System
Immunization
Immunoglobulin G
Leukocyte Count
Lymph Nodes
Lymphocytes
Male
Phenotype
Rats
Rats, Wistar

Source

Open in PubMed

Identifiers

PMID: 15093258
DOI: 10.1016/j.toxlet.2003.12.027

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