Article
The effects of 5-fluorouracil on immunocompetent cells depend on the genotype of experimental animals used.
Immunopharmacology - 1 Jan 2000
Rihova B, Vetvicka V, Kincade P W
Abstract excerpt
A detailed study was made of the effects of 5-fluorouracil (5-FU) on primary and secondary immune responses to a T-dependent antigen in mice. Subcutaneous, intraperitoneal and intravenous applications gave similar results, oral administration was less effective. The minimal effective dose was found to be 40 mg/kg. Inbred strains known to differ in terms of IgG immune responses were compared and found to respond...
Topics
- Animals
- Antibody-Producing Cells
- Bone Marrow
- Erythrocytes
- Female
- Fluorouracil
- Genotype
- Immunoglobulin G
- Immunoglobulin M
- Mice
- Mice, Inbred Strains
- Species Specificity