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Article

The effects of 5-fluorouracil on immunocompetent cells depend on the genotype of experimental animals used.

Immunopharmacology - 1 Jan 2000

Rihova B, Vetvicka V, Kincade P W

Abstract excerpt

A detailed study was made of the effects of 5-fluorouracil (5-FU) on primary and secondary immune responses to a T-dependent antigen in mice. Subcutaneous, intraperitoneal and intravenous applications gave similar results, oral administration was less effective. The minimal effective dose was found to be 40 mg/kg. Inbred strains known to differ in terms of IgG immune responses were compared and found to respond...

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PMID: 3391758
DOI: 10.1016/0162-3109(88)90028-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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