Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of subchronic d-fenfluramine on splenic immune functions in young and old male and female Fischer 344 rats.

International journal of immunopharmacology - 1 Jan 1991

Clancy J, Petrovic L M, Gordon B H, Handa R J, Campbell D B, Lorens S A

Abstract excerpt

The present study was designed to demonstrate age- and sex-related differences in immune functions, and to determine whether subchronic elevations in serotonin (5-HT) availability in vivo would alter immune functions assessed subsequently in vitro. Male and female F344 rats (5 and 21 months of age) were administered the 5-HT releaser and reuptake inhibitor, d-fenfluramine (d-Fen), in their drinking water for...

Topics

Adjuvants, Immunologic
Aging
Animals
B-Lymphocytes
Female
Fenfluramine
Immune System
Killer Cells, Natural
Lymphocyte Activation
Male
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats

Rats, Inbred F344

Sex Characteristics

Spleen

T-Lymphocytes

Source

Identifiers

PMID: 1814854
DOI: 10.1016/0192-0561(91)90171-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1814854-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of subchronic d-fenfluramine on splenic immune functions in young and old male and female Fischer 344 rats.PMID 1814854Read ↗

Genistein modulates splenic natural killer cell activity, antibody-forming cell response, and phenotypic marker expression in F(0) and F(1) generations of Sprague-Dawley rats.Semantic proximity Read ↗

Aging and lymphocyte subsets in the spleen and peripheral blood of the Sprague-Dawley rat.Semantic proximity Read ↗

Modulation of immune response following dietary genistein exposure in F0 and F1 generations of C57BL/6 mice: evidence of thymic regulation.Semantic proximity Read ↗

Genistein and methoxychlor modulate the activity of natural killer cells and the expression of phenotypic markers by thymocytes and splenocytes in F0 and F1 generations of Sprague-Dawley rats.Semantic proximity Read ↗

3-Methylindole-induced splenotoxicity: functional analysis of immune parameters and lymphocyte phenotyping by flow cytometry.Semantic proximity Read ↗

Phenotypic analysis of splenocyte subsets following acute morphine treatment in the rat.Semantic proximity Read ↗

Blood and spleen lymphocytes as targets for immunotoxic effects in the rat--a comparison.Semantic proximity Read ↗

Splenectomy increases blood pressure and abolishes sex differences in renal T-regulatory cells in spontaneously hypertensive rats.Semantic proximity Read ↗

Dietary methoxychlor exposure modulates splenic natural killer cell activity, antibody-forming cell response and phenotypic marker expression in F0 and F1 generations of Sprague Dawley rats.Semantic proximity Read ↗

Aflatoxin B1 modulates the expression of phenotypic markers and cytokines by splenic lymphocytes of male F344 rats.Semantic proximity Read ↗

Validation of immune function testing during a 4-week oral toxicity study with FK506.Semantic proximity Read ↗

Alterations in splenic lymphoid cell subsets and activation antigens in copper-deficient rats.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.