Article
Polymorphisms in glutamate decarboxylase genes: analysis in schizophrenia.
Psychiatric genetics - 1 Mar 2004
De Luca Vincenzo, Muglia Pierandrea, Masellis Mario, Jane Dalton E, Wong Greg W H, Kennedy James L
Abstract excerpt
The decrease of glutamic acid decarboxylase (GAD) has been reported as an important neurochemical alteration of the inhibitory GABAergic interneurons in schizophrenia. To our knowledge no studies have investigated the genetic variants influencing GAD expression. To search for markers contributing to the genetic susceptibility of schizophrenia, we typed two polymorphisms by polymerase chain reaction-restriction...
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