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Article

Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism.

Molecular psychiatry - 1 Aug 2006

Hettema J M, An S S, Neale M C, Bukszar J, van den Oord E J C G, Kendler K S, Chen X

Abstract excerpt

Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders. Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate, and, thus, are reasonable candidate susceptibility genes for these conditions. In this study, we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing...

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Source

Identifiers

PMID: 16718280
DOI: 10.1038/sj.mp.4001845

Genes

GAD1
GAD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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