Article
Mutation screen of the glutamate decarboxylase-67 gene and haplotype association to unipolar depression.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jan 2004
Lappalainen Jaakko, Sanacora Gerard, Kranzler Henry R, Malison Robert, Hibbard Ellen S, Price Lawrence H, Krystal John, Gelernter Joel
Abstract excerpt
Abnormally low concentrations of brain gamma-aminobutyric acid (GABA) have been reported in unipolar depression. Almost all of the brain GABA is synthesized by glutamate decarboxylase (GAD) enzymes (GAD67 and GAD65). These enzymes, therefore, play a central role in brain GABA homeostasis. We screened all the 17 exons of the GAD67 gene for mutations using single strand conformation polymorphism (SSCP) or...
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