Article
Sgt1p and Skp1p modulate the assembly and turnover of CBF3 complexes required for proper kinetochore function.
Molecular biology of the cell - 1 Jul 2004
Rodrigo-Brenni Monica C, Thomas Scott, Bouck David C, Kaplan Kenneth B
Abstract excerpt
Kinetochores are composed of a large number of protein complexes that must be properly assembled on DNA to attach chromosomes to the mitotic spindle and to coordinate their segregation with the advance of the cell cycle. CBF3 is an inner kinetochore complex in the budding yeast Saccharomyces cerevisiae that nucleates the recruitment of all other kinetochore proteins to centromeric DNA. Skp1p and Sgt1p act through...
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