Article
Sgt1 associates with Hsp90: an initial step of assembly of the core kinetochore complex.
Molecular and cellular biology - 1 Sept 2004
Bansal Parmil K, Abdulle Rashid, Kitagawa Katsumi
Abstract excerpt
The kinetochore, which consists of DNA sequence elements and structural proteins, is essential for high-fidelity chromosome transmission during cell division. In budding yeast, Sgt1, together with Skp1, is required for assembly of the core kinetochore complex (CBF3) via Ctf13 activation. Formation of the active Ctf13-Skp1 complex also requires Hsp90, a molecular chaperone. We have found that Sgt1 interacts with...
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