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Article

Hereditary pancreatitis as the premalignant disease: a Japanese case of pancreatic cancer involving the SPINK1 gene mutation N34S.

Pancreas - 1 Apr 2004

Masamune Atsushi, Mizutamari Hiroya, Kume Kiyoshi, Asakura Tooru, Satoh Kennichi, Shimosegawa Tooru

Abstract excerpt

Mutations in the cationic trypsinogen gene are acknowledged as a risk factor for pancreatic cancer in patients with hereditary pancreatitis. However, whether patients with mutations in other genes, such as the serine protease inhibitor Kazal type 1 (SPINK1) gene, are also at a higher risk of pancreatic cancer remains unknown. We report a case of pancreatic cancer associated with chronic calcifying pancreatitis in...

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Source

Identifiers

PMID: 15084977
DOI: 10.1097/00006676-200404000-00018

Genes

SPINK1
PRSS1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hereditary pancreatitis as the premalignant disease: a Japanese case of pancreatic cancer involving the SPINK1 gene mutation N34S.PMID 15084977Read ↗

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