Article
Rare hereditary cause of chronic pancreatitis in a young male: SPINK1 mutation.
The Pan African medical journal - 1 Jan 2017
Patel Janaki, Madan Arina, Gammon Amanda, Sossenheimer Michael, Samadder Niloy Jewel
Abstract excerpt
Hereditary chronic pancreatitis associated with a mutation in the serine protease inhibitor, Kazal Type-1 (SPINK-1 gene) is extremely rare. The SPINK1 mutation results in trypsinogen activation which predisposes to chronic pancreatitis predominately when combined with CFTR gene mutations. It presents as either chronic or recurrent acute pancreatitis. Symptom control and management of complications is important....
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