Article
Metastatic pancreatic adenocarcinoma associated with chronic calcific pancreatitis and a heterozygous SPINK1 N34S mutation.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Jan 2000
Moran Robert A, Klapheke Robert, Jalaly Niloofar Y, Makary Martin A, Hirose Kenzo, Goggins Michael, Wood Laura, Laheru Daniel A, Lennon Anne Marie, Khashab Mouen A, Singh Vikesh K
Abstract excerpt
Contrary to patients with a cationic trypsinogen gene (PRSS1) mutations, Serine protease inhibitor Kazal-type 1 (SPINK1) heterozygote gene mutation carriers have a very low penetrance for acute, acute recurrent and/or chronic pancreatitis. Despite this, heterozygote SPINK 1 gene mutation patients have a similar age of onset of pancreatitis as PRSS 1 gene mutation patients. While the substantially elevated risk of...
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