Article
Mutations in the serine protease inhibitor Kazal Type 1 (SPINK1) gene in Japanese patients with pancreatitis.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Jan 2005
Kume Kiyoshi, Masamune Atsushi, Mizutamari Hiroya, Kaneko Kenzo, Kikuta Kazuhiro, Satoh Masahiro, Satoh Kennichi, Kimura Kenji, Suzuki Noriaki, Nagasaki Yutaka, Horii Akira, Shimosegawa Tooru
Abstract excerpt
BACKGROUND/AIMS: Recent studies have shown an association between the N34S mutation in the serine protease inhibitor Kazal type 1 (SPINK1) gene and chronic pancreatitis (CP). We here examined the prevalence of SPINK1 mutations in Japanese patients with pancreatitis. METHODS: Genomic DNA was prepared from 80 Japanese patients with CP, 36 patients with acute pancreatitis (AP), and 165 healthy controls. All exons...
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