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Article

Analysis of variation in mouse TPMT genotype, expression and activity.

Pharmacogenetics - 1 Apr 2004

Watters James W, Zhang Wanghai, Meucci Melissa A, Hou Weiying, Ma Margaret K, McLeod Howard L

Abstract excerpt

Although the mouse has great potential for pharmacogenomic discovery, little is known about variation in drug response or genetic variation in pharmacologically relevant genes between inbred mouse strains. We therefore assessed variation in gene sequence, mRNA expression and protein activity of thiopurine methyltransferase (TPMT) in multiple inbred mouse strains. TPMT activity was measured by high-performance...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15083069
DOI: 10.1097/00008571-200404000-00004

Genes

TPMT

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