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Article

COT1, a gene involved in cobalt accumulation in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Sept 1992

Conklin D S, McMaster J A, Culbertson M R, Kung C

Abstract excerpt

The COT1 gene of Saccharomyces cerevisiae has been isolated as a dosage-dependent suppressor of cobalt toxicity. Overexpression of the COT1 gene confers increased tolerance to cobalt and rhodium ions but not other divalent cations. Strains containing null alleles of COT1 are viable yet more sensitive to cobalt than are wild-type strains. Transcription of COT1 responds minimally to the extracellular cobalt...

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Identifiers

PMID: 1508175
DOI: 10.1128/mcb.12.9.3678-3688.1992
PMCID: PMC360222

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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