Article
COT1, a gene involved in cobalt accumulation in Saccharomyces cerevisiae.
Molecular and cellular biology - 1 Sept 1992
Conklin D S, McMaster J A, Culbertson M R, Kung C
Abstract excerpt
The COT1 gene of Saccharomyces cerevisiae has been isolated as a dosage-dependent suppressor of cobalt toxicity. Overexpression of the COT1 gene confers increased tolerance to cobalt and rhodium ions but not other divalent cations. Strains containing null alleles of COT1 are viable yet more sensi...
Topics
- Amino Acid Sequence
- Base Sequence
- Biological Transport
- Cation Transport Proteins
- Cloning, Molecular
- Cobalt
- DNA, Fungal
- Drug Resistance, Microbial
- Fungal Proteins
- Genes, Fungal
- Immunoblotting
- Intracellular Membranes
- Membrane Transport Proteins
- Mitochondria
- Molecular Sequence Data
- Phenotype
- Restriction Mapping
- Saccharomyces cerevisiae