Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast.

Molecular genetics and genomics : MGG - 1 Aug 2012

Ryuko Sayomi, Ma Yan, Ma Ning, Sakaue Motoyoshi, Kuno Takayoshi

Abstract excerpt

Cobalt is an essential micronutrient but is toxic when present in excess. To study cobalt homeostasis we performed a genome-wide screen for deletion strains that show sensitivity or resistance to CoCl(2). Among 54 cobalt-sensitive strains, 18 are supersensitive strains, which are involved in histidine biosynthetic process, ubiquitination, mitochondria function, membrane trafficking, transporter and a variety of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cobalt
Share to Gene Deletion
Share to Genome, Fungal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Membrane Transport Proteins

Share to Mitogen-Activated Protein Kinases

Share to Schizosaccharomyces

Share to Schizosaccharomyces pombe Proteins

Share to Signal Transduction

Source

Identifiers

PMID: 22806344
DOI: 10.1007/s00438-012-0705-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast.PMID 22806344Read ↗

Mechanisms other than activation of the iron regulon account for the hyper-resistance to cobalt of a Saccharomyces cerevisiae strain obtained by evolutionary engineering.Semantic proximity Read ↗

A maize Ni2+/Co2+ transporter ZL1 maintains cobalt and nickel homeostasis and contributes to photosynthesis.Semantic proximity Read ↗

<i>GEF1</i> Is a Novel Factor Regulating Nickel Ion Metabolism in <i>Saccharomyces cerevisiae</i>Semantic proximity Read ↗

The yeast iron regulon is induced upon cobalt stress and crucial for cobalt tolerance.Semantic proximity Read ↗

Gain-of-function mutations identify amino acids within transmembrane domains of the yeast vacuolar transporter Zrc1 that determine metal specificity.Semantic proximity Read ↗

MTM1 plays an important role in the regulation of zinc tolerance in Saccharomyces cerevisiae.Semantic proximity Read ↗

ZNT1 involves cuproptosis through regulating MTF1-conduced expression of MT1X under copper overloadSemantic proximity Read ↗

Zinc transporters belonging to the Cation Diffusion Facilitator (CDF) family have complementary roles in transporting zinc out of the cytosol.Semantic proximity Read ↗

Gene expression profiling and phenotype analyses of S. cerevisiae in response to changing copper reveals six genes with new roles in copper and iron metabolism.Semantic proximity Read ↗

COT1, a gene involved in cobalt accumulation in Saccharomyces cerevisiae.Semantic proximity Read ↗

A functional screen for copper homeostasis genes identifies a pharmacologically tractable cellular system.Semantic proximity Read ↗

A genome-wide deletion mutant screen identifies pathways affected by nickel sulfate in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.