Article
The putative transcriptional activator MSN1 promotes chromium accumulation in Saccharomyces cerevisiae.
Molecules and cells - 31 Dec 2003
Chang Kwang Suk, Won Jong Im, Lee Mi Ran, Lee Chang Eun, Kim Kyongmin Hwang, Park Ky Young, Kim Seong-Ki, Lee June Seung, Hwang Seongbin
Abstract excerpt
Yeast is a good system for studying molecular mechanisms of metal tolerance. Using a mini-Tn mutagenized yeast pool, we isolated a chromate-tolerant mutant, CrT9, that displayed metal-specific tolerance since it was only tolerant to Cr(VI), not to Cr(III), Cd, As, or Fe. The Cr-tolerance of CrT9 appeared to be due to reduced Cr accumulation as it accumulated only 56% as much as WT (Y800). Using IPCR (inverse...
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