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Article

A yeast metal resistance protein similar to human cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein.

The Journal of biological chemistry - 9 Sept 1994

Szczypka M S, Wemmie J A, Moye-Rowley W S, Thiele D J

Abstract excerpt

Members of the ATP binding cassette (ABC) protein superfamily transport a variety of substances across biological membranes, including drugs, ions, and peptides. The yeast cadmium factor (YCF1) gene from Saccharomyces cerevisiae is required for cadmium resistance and encodes a 1,515 amino acid protein with extensive homology to both the human multidrug resistance-associated protein (MRP1) and the cystic fibrosis...

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Identifiers

PMID: 7521334

Genes

CFTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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A yeast metal resistance protein similar to human cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein.PMID 7521334Read ↗

ABC Transporters in Saccharomyces cerevisiae and Their Interactors: New Technology Advances the Biology of the ABCC (MRP) SubfamilySemantic proximity Read ↗

The multidrug resistance-associated protein (MRP) subfamily (Yrs1/Yor1) of Saccharomyces cerevisiae is important for the tolerance to a broad range of organic anions.Semantic proximity Read ↗

Negative Regulation of the Yeast ABC Transporter Ycf1p by Phosphorylation within Its N-terminal ExtensionSemantic proximity Read ↗

Structure of Ycf1p reveals the transmembrane domain TMD0 and the regulatory region of ABCC transportersSemantic proximity Read ↗

The function of Alr1p of Saccharomyces cerevisiae in cadmium detoxification: insights from phylogenetic studies and particle-induced X-ray emission.Semantic proximity Read ↗

Ycf1p-dependent Hg(II) detoxification in Saccharomyces cerevisiae.Semantic proximity Read ↗

Identification of mutations allowing Natural Resistance Associated Macrophage Proteins (NRAMP) to discriminate against cadmium.Semantic proximity Read ↗

Gain-of-function mutations identify amino acids within transmembrane domains of the yeast vacuolar transporter Zrc1 that determine metal specificity.Semantic proximity Read ↗

Identification of genes involved in the toxic response of Saccharomyces cerevisiae against iron and copper overload by parallel analysis of deletion mutants.Semantic proximity Read ↗

Mutational analysis of Saccharomyces cerevisiae Smf1p, a member of the Nramp family of metal transporters.Semantic proximity Read ↗

Cd2+, Mn2+, Ni2+ and Se2+ toxicity to Saccharomyces cerevisiae lacking YPK9p the orthologue of human ATP13A2Semantic proximity Read ↗

Requirement of the N-terminal extension for vacuolar trafficking and transport activity of yeast Ycf1p, an ATP-binding cassette transporter.Semantic proximity Read ↗

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