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Article

Regulation of the SM-20 prolyl hydroxylase gene in smooth muscle cells.

Biochemical and biophysical research communications - 7 May 2004

Menzies Keon, Liu Bin, Kim William J H, Moschella Maria C, Taubman Mark B

Abstract excerpt

SM-20 encodes an intracellular prolyl hydroxylase that acts on hypoxia inducible factor (HIF)-1alpha, targeting it for proteasomal degradation. By decreasing HIF-alpha, SM-20 is thought to modulate the expression of hypoxia-regulated genes. SM-20 expression in the arterial wall is restricted to smooth muscle cells, which play a critical role in atherosclerosis and arterial injury. To further elucidate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle, Smooth, Vascular

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Source

Identifiers

PMID: 15081411
DOI: 10.1016/j.bbrc.2004.03.115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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