Article
Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease.
Neuromolecular medicine - 1 Jan 2004
Busby Victoria, Goossens Steven, Nowotny Petra, Hamilton Gillian, Smemo Scott, Harold Denise, Turic Dragana, Jehu Luke, Myers Amanda, Womick Meredith, Woo Daniel, Compton Danielle, Doil Lisa M, Tacey Kristina M, Lau Kit F, Al-Saraj Safa, Killick Richard, Pickering-Brown Stuart, Moore Pamela, Hollingworth Paul, Archer Nicola, Foy Catherine, Walter Sarah, Lendon Corrine, Iwatsubo Takeshi, Morris John C, Norton Joanne, Mann David, Janssens Barbara, Hardy John, O'Donovan Michael, Jones Lesley, Williams Julie, Holmans Peter, Owen Michael J, Grupe Andrew, Powell John, van Hengel Jolanda, Goate Alison, Van Roy Frans, Lovestone Simon
Abstract excerpt
The gene encoding alpha-T-catenin, CTNNA3, is positioned within a region on chromosome 10, showing strong evidence of linkage to Alzheimer's disease (AD), and is therefore a good positional candidate gene for this disorder. We have demonstrated that alpha-T-catenin is expressed in human brain, and like other alpha-catenins, it inhibits Wnt signaling and is therefore also a functional candidate. We initially...
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