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Article

Lack of an association between Alzheimer's disease and the cystatin C (CST3) gene G73A polymorphism in Mainland Chinese.

Dementia and geriatric cognitive disorders - 1 Jan 2008

Wang Binbin, Xie Yan-chen, Yang Ze, Peng Dantao, Wang Jing, Zhou Sirui, Li Shu, Ma Xu

Abstract excerpt

Alzheimer's disease (AD) is a complex multifactorial disorder involving a number of genetic and environmental factors. Cystatin C (CST3), which belongs to the type II cystatin gene family, is a potent inhibitor of lysosomal proteinases. Immunohistochemical studies have demonstrated the colocalization of the b-amyloid (A-beta) and cystatin C peptides within arteriolar walls in the AD brain. The G73A polymorphism...

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Source

Identifiers

PMID: 18408364
DOI: 10.1159/000125670

Genes

CST3
APOE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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