Article
No association between the cystatin C gene polymorphism and Alzheimer's disease: a case-control study in an Italian population.
Journal of Alzheimer's disease : JAD - 1 Aug 2005
Monastero Roberto, Camarda Cecilia, Cefalù Angelo B, Caldarella Rosalia, Camarda Lawrence K C, Noto Davide, Averna Maurizio R, Camarda Rosolino
Abstract excerpt
Cystatin C is an amyloidogenic protein found together with beta-amyloid in cerebral arteriolar walls of both patients with Alzheimer's Disease (AD) and conghopilic amyloid angiopathy. Several findings implicate cystatin C in the pathogenesis of vascular diseases. Recent genetic association studies proposed cystatin C gene (CST3) as a susceptibility factor for AD, although other reports did not replicate this...
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