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Article

Leptin and the onset of puberty: insights from rodent and human genetics.

Seminars in reproductive medicine - 1 May 2002

Farooqi I Sadaf

Abstract excerpt

Deficiency of the adipocyte-derived hormone leptin in ob/ob mice results in severe, early-onset obesity and infertility. Administration of leptin results in complete reversal of the phenotype, suggesting that leptin is needed for the development of puberty in rodents. In humans, mutations in the...

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Source

Identifiers

PMID: 12087499
DOI: 10.1055/s-2002-32505

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12087499-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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