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Article

Tyrosine phosphorylation of NOS3 in a breast cancer cell line and Src-transformed cells.

Oncology reports - 1 May 2004

Takenouchi Yasushi, Oo Myat Lin, Senga Takeshi, Watanabe Yasuo, Machida Kazuya, Miyazaki Kou, Nimura Yuji, Hamaguchi Michinari

Abstract excerpt

We investigated the tyrosine phosphorylation of NOS3 by active Src. In a cell line derived from human breast cancer, BT474, we found activation of c-Src and tyrosine phosphorylation of NOS3. Phosphorylation of NOS3 was suppressed by treatment of BT474 with PP1, an Src kinase inhibitor, in a dose-dependent manner, suggesting that phosphorylation of NOS3 is catalyzed by active c-Src. Phosphorylation of NOS3 was...

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PMID: 15069547

Genes

NOS3
NOS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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