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Article

Influence of ApoA-I structure on the ABCA1-mediated efflux of cellular lipids.

The Journal of biological chemistry - 26 Nov 2004

Vedhachalam Charulatha, Liu Lijuan, Nickel Margaret, Dhanasekaran Padmaja, Anantharamaiah G M, Lund-Katz Sissel, Rothblat George H, Phillips Michael C

Abstract excerpt

The influence of apolipoprotein (apo) A-I structure on ABCA1-mediated efflux of cellular unesterified (free) cholesterol (FC) and phospholipid (PL) is not well understood. To address this issue, we used a series of apoA-I mutants to examine the contributions of various domains in the molecule to ABCA1-mediated FC and PL efflux from mouse J774 macrophages and human skin fibroblasts. Irrespective of the cell type,...

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Source

Identifiers

PMID: 15383537
DOI: 10.1074/jbc.M406924200

Genes

ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Influence of ApoA-I structure on the ABCA1-mediated efflux of cellular lipids.PMID 15383537Read ↗

Effect of apoA-I Mutations in the Capacity of Reconstituted HDL to Promote ABCG1-Mediated Cholesterol Efflux.Semantic proximity Read ↗

The central helices of ApoA-I can promote ATP-binding cassette transporter A1 (ABCA1)-mediated lipid efflux. Amino acid residues 220-231 of the wild-type ApoA-I are required for lipid efflux in vitro and high density lipoprotein formation in vivo.Semantic proximity Read ↗

ABCA1 mutants reveal an interdependency between lipid export function, apoA-I binding activity, and Janus kinase 2 activation.Semantic proximity Read ↗

The effects of mutations in helices 4 and 6 of ApoA-I on scavenger receptor class B type I (SR-BI)-mediated cholesterol efflux suggest that formation of a productive complex between reconstituted high density lipoprotein and SR-BI is required for efficient lipid transport.Semantic proximity Read ↗

Apolipoprotein A-I-stimulated apolipoprotein E secretion from human macrophages is independent of cholesterol efflux.Semantic proximity Read ↗

Carboxyl terminus of apolipoprotein A-I (ApoA-I) is necessary for the transport of lipid-free ApoA-I but not prelipidated ApoA-I particles through aortic endothelial cells.Semantic proximity Read ↗

The role of apolipoprotein A-I helix 10 in apolipoprotein-mediated cholesterol efflux via the ATP-binding cassette transporter ABCA1.Semantic proximity Read ↗

ABCA1 and amphipathic apolipoproteins form high-affinity molecular complexes required for cholesterol efflux.Semantic proximity Read ↗

Structure-function studies of apoA-I variants: site-directed mutagenesis and natural mutations.Semantic proximity Read ↗

ApoA-I dissociated from human HDL retains its acceptor properties in ABCA1-mediated cholesterol efflux from RAW 264.7 macrophages in coronary artery diseaseSemantic proximity Read ↗

Scavenger receptor class B type I-mediated cholesteryl ester-selective uptake and efflux of unesterified cholesterol. Influence of high density lipoprotein size and structure.Semantic proximity Read ↗

SR-BI mediates cholesterol efflux via its interactions with lipid-bound ApoE. Structural mutations in SR-BI diminish cholesterol efflux.Semantic proximity Read ↗

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