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Article

Glutathione S-transferases and aromatic DNA adducts in smokers' bronchoalveolar macrophages.

Lung cancer (Amsterdam, Netherlands) - 1 Mar 2003

Piipari Ritva, Nurminen Tuula, Savela Kirsti, Hirvonen Ari, Mäntylä Timo, Anttila Sisko

Abstract excerpt

Interindividual differences in the expression of carcinogen-metabolizing enzymes in the lung may modify the effective dose of tobacco carcinogens in this organ. We investigated the role of detoxifying glutathione S-transferases (GST) in the formation of aromatic DNA adducts in bronchoalveolar macrophages (BAM) of active smokers. The effect of GSTs on aromatic DNA adducts was studied separately and in combination...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 Enzyme System

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Share to Macrophages, Alveolar

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Source

Identifiers

PMID: 12609564
DOI: 10.1016/s0169-5002(02)00510-x

Genes

GSTM3
GSTM1
GSTP1
PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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