Absolute requirement of cyclic nucleotide in the activation of the G141Q mutant cAMP receptor protein from Escherichia coli.

Article

Absolute requirement of cyclic nucleotide in the activation of the G141Q mutant cAMP receptor protein from Escherichia coli.

The Journal of biological chemistry - 9 Dec 1994

Cheng X, Lee J C

Abstract excerpt

cAMP receptor protein (CRP), when interacting with cAMP, controls the expression of a network of catabolite-sensitive genes in Escherichia coli. To understand the molecular events that lead to the activation of CRP, a combined approach of site-directed mutagenesis and thermodynamic analysis was e...

Topics

Base Sequence
Cyclic AMP
Cyclic AMP Receptor Protein
Cyclic CMP
Cyclic GMP
Escherichia coli
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.