Article
Resistance of mitochondrial p53 to dominant inhibition.
Molecular cancer - 12 Jun 2008
Heyne Kristina, Schmitt Katrin, Mueller Daniel, Armbruester Vivienne, Mestres Pedro, Roemer Klaus
Abstract excerpt
BACKGROUND: Mutation of a tumor suppressor allele leaves the second as backup. Not necessarily so with p53. This homo-tetrameric transcription factor can become contaminated with mutant p53 through hetero-tetramerization. In addition, it can be out-competed by the binding to p53 DNA recognition motifs of transactivation-incompetent isoforms (DeltaN and DeltaTA-isoforms) of the p53/p63/p73 family of proteins....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.