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Article

Toxicokinetic genetics: an approach to gene-environment and gene-gene interactions in complex metabolic pathways.

IARC scientific publications - 1 Jan 2004

Cortessis Victoria, Thomas Duncan C

Abstract excerpt

We propose an approach to modelling the joint effects of multiple genes involved in metabolic activation and detoxification of environmental exposures. A physiologically based pharmacokinetic (PBPK) model is used, in which the various person-specific metabolic rates are related to measurements of...

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Share to Arylamine N-Acetyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP1A1

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Source

Identifiers

PMID: 15055294

Genes

EPHX1
GSTM3
NAT1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15055294-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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