Structure of epidemiological studies on genetic susceptibility to environmental toxicants.

Abstract excerpt

Metabolic genes code for enzymes that are involved in conjugation and detoxification of environmental toxicants. Polymorphisms in these genes result in individual differences in susceptibility to carcinogens and therefore in differences in cancer risk. The most common study design used in the area of genetic susceptibility is the case-control study, because of both economic and logistic constraints. Since...

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