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Article

The fusion proteins TEL-PDGFRbeta and FIP1L1-PDGFRalpha escape ubiquitination and degradation.

Haematologica - 1 Aug 2009

Toffalini Federica, Kallin Anders, Vandenberghe Peter, Pierre Pascal, Michaux Lucienne, Cools Jan, Demoulin Jean-Baptiste

Abstract excerpt

BACKGROUND: Chimeric oncogenes encoding constitutively active protein tyrosine kinases are associated with chronic myeloid neoplasms. TEL-PDGFRbeta (TPbeta, also called ETV6-PDGFRB) is a hybrid protein produced by the t(5;12) translocation, FIP1L1-PDGFRalpha (FPalpha) results from a deletion on chromosome 4q12 and ZNF198-FGFR1 is created by the t(8;13) translocation. These fusion proteins are found in patients...

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Source

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Identifiers

PMID: 19644140
DOI: 10.3324/haematol.2008.001149
PMCID: PMC2719031

Genes

FGFR1
ETV6
PDGFRB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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