Article
Detection of c-kit mutations in canine mast cell tumors using fluorescent polyacrylamide gel electrophoresis.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc - 1 Mar 2004
Jones Cameron L R, Grahn Robert A, Chien May B, Lyons Leslie A, London Cheryl A
Abstract excerpt
Mutations consisting of internal tandem duplications (ITDs) in exons 11 and 12 of the proto-oncogene c-kit are found in 30-50% of malignant canine mast cell tumors (MCTs). Traditionally, identification of such mutations in tumor specimens has been undertaken using standard polymerase chain reacti...
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